Abstract Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress.However, the molecular mechanisms by which p53 controls gene transcription are not completely understood.Here, we uncover the critical role of spatio-temporal genome architecture in this process.We demonstrate that p53 drives di

Background: Colon cancer is uncommon in children.This article reports a case of signet ring cell carcinoma in an 11-year-old child who presented with acute intestinal obstruction.Case report: An 11-year-old boy presented with progressive abdominal distension TRI B12 SYNERGY associated with constipation.The child underwent an abdominal X-ray in the

This paper assesses Basters the interface stability of the perovskite CsPbBr3 and transport layer CuI using density functional theory and band offset calculations.As a low-cost, more stable alternative to current hole transport materials, CuI may be used to template the epitaxial growth of perovskites such as CsPbBr3 owing to a 1% lattice constant

Clutch components rotating at high speed remain under the influence of high centrifugal forces.Therefore at the high rotational speeds flywheel is subjected to extreme forces that may cause severe cracks and breakages.Burst test validates the mechanical robustness of the flywheel under various rotational speeds.In this study comparative analysis ha